In human clinical studies, SytrinolTM given at a dose of 150 mg twice daily (daily dose of 300 mg) to hypercholesterolemic subjects for 4 weeks resulted in:
´ Reductions of total cholesterol by 20-24%
´ Reductions in LDL- cholesterol by 19-22%
´ Reducations in triglycerides by 24-28%
´ Significant improvement of LDL/HDL ratio
Larger and longer follow up studies involving 120 hypercholesterolemic subjects supplemented for 12 weeks have yielded similar findings.
What is Sytrinol®?
Sytrinol® is a unique and powerful ingredient for maintaining cholesterol health. The healthful effects of both bioflavonoids as well as tocotrienols have been recognized for years. Sytrinol® provides a patented and well-researched combination of flavonoids derived from the peel of tangerines and tocotrienols derived palm. Science on the anti-inflammatory and antioxidant actions of these supplements date back to the 1960's. These supplements have been shown to improve cholesterol metabolism by decreasing the basic components needed for making LDL-cholesterol. Two components of this product (nobiletin and tangeretin) have also been shown to decrease an enzyme in the liver involved in the synthesis of triglycerides.
Sytrinol® also contains a group of compounds belonging to the vitamin E family. These compounds have been studied over the years for their ability to act as antioxidants and to help support cardiovascular health. Tocotrienols have been shown to inhibit the enzyme responsible for the rate limiting step in the synthesis of cholesterol.
Consequently, the combined action of the supplements contained in Sytrinol results in a powerful synergistic action to support cardiovascular health. This effect has been confirmed in both animal as well as human studies.
What are Plant Sterols?
Plant sterols are naturally occurring plant compounds that have structures similar to, yet slightly different from cholesterol. Typical plant sterols are compounds such as ß-sitosterol, campesterol, and stigmasterol and can be found in vegetables, fruits, legumes, nuts, grains and certainoils.
Research has shown that these compounds compete with the absorption of dietary cholesterol as well as inhibit the reabsorption of cholesterol in the gastrointestinal tract. Supplementation with plant sterols can significantly lower cholesterol levels and have been shown to work synergistically with other therapies for lowering cholesterol. Numerous foods including orange juice, rice drink, and margarine now incorporate plant sterols, or sterol esters. Increasingly, dietary supplements are now incorporating plant sterols and using the health claim that has been allowed for products containing at least 800 mg of plant sterols daily. The addition of plant sterols to Cardio Engage provides yet another mechanism by which healthy cholesterol levels can be maintained.
Recent science has been focusing on the cardioprotective aspects of pomegranate. These brightly colored fruits contain numerous compounds known for their antioxidant capabilities. Research has shown that supplementation with pomegranate juice can decrease macrophage lipid accumulation, and cellular cholesterol accumulation in mice.
Recently, research in humans has confirmed a beneficial effect of consuming pomegranate juice on LDL oxidation, blood pressure, and blood vessel health.
The combination of Sytrinol®, plant sterols, and pomegranate extract present in Cardio Engage results in a formula that embodies the most recent science to help maintain cardiovascular health and support healthy cholesterol levels.